Author: Dom Bennett
" R packages for interacting with the National Center for Biotechnology Information (NCBI) have, to-date, depended on API query calls via NCBI’s Entrez. For computational analyses that require the automated look-up of reams of biological sequence data, piecemeal querying via bandwith-limited requests is evidently not ideal.
…
restez attempts to make large queries to NCBI GenBank more efficient by allowing users to download whole sections of GenBank, create a local database from these downloaded files and then query this mini-GenBank version instead."
Read the full Tech Note for more info and a short use case: https://ropensci.org/technotes/2018/12/03/restez/