A few weeks ago, prof Matt Crump wrote a blog post in which he explores tools to handle MIDI data in R, in preparation for a cognition experiment that involves creating musical stimuli. In the article he ends up using a mix of external command line tools ffmpeg and fluidsynth and a python module.
This is a companion discussion topic for the original entry at https://ropensci.org/blog/2024/02/20/fluidsynth